Biofreeze Pain Relieving Gel 16oz COL635 For 20 years Biofreeze products have been helping people manage their discomfort by offering a variety of benefits that assist in therapy, pain relief, exercise/training and overall comfort. Using menthol as the active ingredient, Biofreeze penetrates quickly, preventing or relieving pain through cold therapy. Biofreeze products help you do more with less pain. Biofreeze Pain Relieving Gel dispensed from a tube affords the opportunity to create a more thorough experience by massaging the affected area during application. This hands-on application also reinforces touch which has been shown to be very important in the healing cycle.